Novel – Harp Maker http://harpmaker.net/ Mon, 03 Jan 2022 08:05:57 +0000 en-US hourly 1 https://wordpress.org/?v=5.8 https://harpmaker.net/wp-content/uploads/2021/06/cropped-icon-32x32.png Novel – Harp Maker http://harpmaker.net/ 32 32 New Zealand’s first Booker Prize winner Keri Hulme dies at 74 https://harpmaker.net/new-zealands-first-booker-prize-winner-keri-hulme-dies-at-74/ Mon, 03 Jan 2022 07:49:44 +0000 https://harpmaker.net/new-zealands-first-booker-prize-winner-keri-hulme-dies-at-74/ After attending North New Brighton Primary School and Aranui Secondary School in Christchurch, Ms Hulme worked for a season picking hops and tobacco in the Tasman area before briefly studying law at the University of Canterbury. She went on to do odd jobs across the country before working at the post office in the rural […]]]>

After attending North New Brighton Primary School and Aranui Secondary School in Christchurch, Ms Hulme worked for a season picking hops and tobacco in the Tasman area before briefly studying law at the University of Canterbury.

She went on to do odd jobs across the country before working at the post office in the rural town of Greymouth, on the remote west coast of New Zealand’s South Island. She believed it would give her time and space to write.

It was there that she learned to bait or catch tiny, transparent juvenile fish. It was an “obsession,” as she put it, that sustained her for the rest of her life. Dr Evans recalled that she routinely ran away from a writing residence with a net to catch white bait strapped to the roof of her car.

“You would see that white bait net, sort of walk through the parking lot and you knew she was running away,” he said.

Ms Hulme continued to live primarily on the West Coast, including for more than four decades in the small New Zealand settlement of Okarito, a former gold mining village, on land she won from the lottery in 1973. When she had lived further inland, she told Flash Frontier magazine in 2012, “I’m depressed and sick, I drink too much and I don’t do anything creative.”

Both shy with strangers and a generous and sociable host to those she loved, Ms. Hulme was not interested in romantic or sexual relationships, calling herself “neutral”. She never married or had children. She is survived by two sisters, Kate Salmons and Diane McAuliffe, and one brother, John Hulme, as well as several nieces and nephews.

“If you knew her, if she knew you, she would take the time and move heaven and earth to give you time and spend that time well,” said Matthew Salmons, her nephew. “The family she was born into and the family she created were of the utmost importance to her.”


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Visual Novel ‘Marshmallow All The Way Home’ arrives West via Johren on January 7th https://harpmaker.net/visual-novel-marshmallow-all-the-way-home-arrives-west-via-johren-on-january-7th/ Sat, 01 Jan 2022 15:22:45 +0000 https://harpmaker.net/visual-novel-marshmallow-all-the-way-home-arrives-west-via-johren-on-january-7th/ Shiravune has announced that a new visual novel by Marmalade is coming west. Marshmallow home will be available on PC -via Johren- on January 7th. As with Primal Hearts, Primal Hearts 2 and Study Steady, the English edition is an 18+ version. Known in Japan as Ouchi ni Kaeru Made ga Mashimaro Desu, the game […]]]>

Shiravune has announced that a new visual novel by Marmalade is coming west. Marshmallow home will be available on PC -via Johren- on January 7th. As with Primal Hearts, Primal Hearts 2 and Study Steady, the English edition is an 18+ version.

Known in Japan as Ouchi ni Kaeru Made ga Mashimaro Desu, the game tells the story of a boy called Ryou. After being evicted from his home, he is fortunate enough to get new housing by working in a pastry shop called Marshmallow Tree. As stiff competition threatens the store’s sustainability, he will have to work hard to help young owner Kanon Kasukabe (CV: Maya Suzuya).

However, along the way, he will have the chance to become more intimate with her and three other girls, each having different relationships with Marshmallow Tree. One of them is Ushio Asaka (CV: Kiiro Tsukino), a childhood friend of Kanon who frequently helps him. Another is Sasa Misuzu (CV: Yuina), who is a regular there and hopes to someday become a picture book author.

He can also enjoy the company of Raiha Räikkönen (CV: Wakana Seraki), a young girl who doesn’t like pastries despite her job at rival store Souvenir. The game is produced by Yoshimi Takeuchi, whose previous work includes the three Marmalade games already published by Shiravune in English (Primal Hearts, Primal Hearts 2 and Study Steady).

Discover some Marshmallow home screenshots below:


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New detective story inspired by cold real-life affair – Oakland News Now https://harpmaker.net/new-detective-story-inspired-by-cold-real-life-affair-oakland-news-now/ Thu, 30 Dec 2021 23:24:37 +0000 https://harpmaker.net/new-detective-story-inspired-by-cold-real-life-affair-oakland-news-now/ https://www.youtube.com/watch?v=iXcmLCJQAOs Oakland News Now – New detective story inspired by a real cold case – video made by the YouTube channel with the logo in the upper left corner of the video. OaklandNewsNow.com is the original blog post for this type of video blog content. Best-selling author and physician Dr. Ian Smith discusses his detective […]]]>

https://www.youtube.com/watch?v=iXcmLCJQAOs

Oakland News Now –

New detective story inspired by a real cold case

– video made by the YouTube channel with the logo in the upper left corner of the video. OaklandNewsNow.com is the original blog post for this type of video blog content.

Best-selling author and physician Dr. Ian Smith discusses his detective novel, “Wolf Point”.

Going through IFTTT

Note from Zennie62Media and OaklandNewsNow.com: This video blog post shows the full, live operation of the latest updated version of an experimental network of Zennie62Media, Inc. mobile multimedia video blogging system that was launched in June 2018 This is an important part of Zennie62Media, Inc.’s new and innovative approach to news media production. What we call “the third wave of media”. The uploaded video is from a YouTube channel. When ABC’s Good Morning America YouTube video channel uploads a video, it is automatically uploaded and automatically formatted on the Oakland News Now site and on social media pages created and owned by Zennie62. The overall goal here, in addition to our is the real-time on-scene reporting of news, interviews, sightings and events all over the world and in seconds, not hours – is the use of the network existing YouTube social. graphic on any topic in the world. Now the news is reported with a smartphone and also by promoting the current content on YouTube: no heavy and expensive camera or even a laptop is needed, nor to have a camera crew to film what is already on Youtube. The secondary objective is faster and very inexpensive production and distribution of media content information. We have found that there is a lag between the length of the post and the production time and revenue generated. With this the problem is much less, but by no means solved. Zennie62Media is constantly striving to improve the system’s network coding and is looking for interested multimedia content and technology partners.

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Steven R. Jones’ New Book “The Coded Note” Brings Mystery Novel About Murder Case Soon To Shake The Life Of A Pastor https://harpmaker.net/steven-r-jones-new-book-the-coded-note-brings-mystery-novel-about-murder-case-soon-to-shake-the-life-of-a-pastor/ Wed, 29 Dec 2021 05:00:00 +0000 https://harpmaker.net/steven-r-jones-new-book-the-coded-note-brings-mystery-novel-about-murder-case-soon-to-shake-the-life-of-a-pastor/ HOLLAND, Mich., December 29, 2021 / PRNewswire-PRWeb / – Steven r jones, writer and production engineer, has completed her new book “The Coded Note”: A Heartbreaking Story that follows Pastor Sarah as she and a detective attempt to unravel clues about her friend’s homicide by decoding a note left behind by the dead. Jones shares: […]]]>

HOLLAND, Mich., December 29, 2021 / PRNewswire-PRWeb / – Steven r jones, writer and production engineer, has completed her new book “The Coded Note”: A Heartbreaking Story that follows Pastor Sarah as she and a detective attempt to unravel clues about her friend’s homicide by decoding a note left behind by the dead.

Jones shares: “Sarah did not expect that when she was called to preach it would totally ruin her social life. In her first pastorate she struggled with loneliness but would not give up what she believed. be her life’s work, and she quit to live on her own.

One tragic day, she found the body of the closest friend she had. Next to the deceased was a note beginning with “Dear Pasteur Sarah”. It was clearly written around the hour of death. There were several entries in the diary for her to think about. It was definitely written for her; so she took it, not knowing that it contained a code on the identity of the killer. When she took the note, she had no idea it would make a young detective angry. But as he works on the case, he realizes that in order to solve this crime he has to have Sarah’s expertise. “

Published by Page Publishing, Steven R. Jones’ Captivating fiction is a gripping experience where events do not unfold as you expect. Join Pastor Sarah as she works her expertise on a mystery that may unblock other questions that already exist.

Readers who wish to experience this exciting work can purchase “The Coded Note” in bookstores around the world, or online at the Apple iTunes Store, Amazon, Google Play, or Barnes and Noble.

For more information or for media inquiries, contact Page Publishing at 866-315-2708.

About publishing pages:

Page Publishing is a traditional full-service publishing house that handles all of the intricacies involved in publishing its authors’ books, including distribution to the world’s largest retail outlets and royalty generation. Page Publishing understands that authors should be free to create, not bogged down in logistics like converting eBooks, setting up wholesale accounts, insurance, shipping, taxes, and more. Page writers and publishing professionals allow authors to leave these complex and time-consuming problems behind and focus on their passion – writing and creating. Learn more about http://www.pagepublishing.com.

Media contact

Pages Publishing Media Department, Pages Publishing, 1-866-315-2708, media@pagepublishing.com

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“Such a good time”: Austin author Vanessa King’s debut novel is a mix of Jane Austen and burlesque https://harpmaker.net/such-a-good-time-austin-author-vanessa-kings-debut-novel-is-a-mix-of-jane-austen-and-burlesque/ Mon, 27 Dec 2021 10:48:57 +0000 https://harpmaker.net/such-a-good-time-austin-author-vanessa-kings-debut-novel-is-a-mix-of-jane-austen-and-burlesque/ Austin author Vanessa King has just released her first novel, A certain attraction, which is a story by Jane Austen Pride and Prejudice set in the world of modern burlesque in New York. King herself spent time in this world a few years ago and knew she wanted to use this environment as the setting […]]]>

Austin author Vanessa King has just released her first novel, A certain attraction, which is a story by Jane Austen Pride and Prejudice set in the world of modern burlesque in New York. King herself spent time in this world a few years ago and knew she wanted to use this environment as the setting for a book – she just didn’t know what story she wanted to tell.

“Having worked in a show, I had in mind that it would just be a perfect setting for a story,” she says. “But the plot is still the sticking point for me. If I had my druthers, it would only be well-adjusted, intelligent people floating in space, joking around.

A conversation with a friend and fellow writer gave her the prompt she needed, King says. “I was chatting with a friend… and she mentioned that she was working on a story,” she says. “She was doing The Wizard of Oz at a music festival. And I was like, ‘Ooh. Tell ! Do. Okay.'”

King began to describe that night, quickly choosing Pride and Prejudice like his model. “I don’t know if it was because it was the first real classic I read and has stuck in my head ever since,” she says. “But yeah. That was the starting point and I went from there.

“The characters kind of crept in – you know, you’ve got the framework of personalities based on Austen’s characters,” King says. “But instead of having a group of five sisters, it’s more of a kind of found family, with people who work on the show. So you have the stage kitten, which is the one who picks up what everyone else takes. And that’s the main character, Elizabeth. Where Kitten Kaboodle is her stage name.

King was inspired for her protagonist by the work she herself did for two years at Duane Park, the famous New York club Burlesque. “I took classes with the New York School of Burlesque and ended up doing a student showcase. I did two, and my only routine was on the Oogie theme from The nightmare before Christmas, “she said.” But I wasn’t good. I mean, it wasn’t bad. But it was one of those things that would take a lot more commitment… to really get good. so wrote to the principal of the New York School of Burlesque because she had suggested kittens for those who maybe didn’t have all the time to commit. And she suggested that I go to Duane Park. So I just had a shift for a while, and that was great! Picked up after the best. It was such a good time. I mean, the only wait of the burlesque – for the artists and the crowd – is that you have fun, that you have fun, and that shows in every show you attend.

King says she knew while she was immersed in the burlesque scene that she would one day write about it. “It was just memorable,” she says. “It was just such a good time. I mean, it reads like fiction – you experience it and you say to yourself, is it real? It feels like we’re in another world anyway.

‘A Certain Appeal’ by Vanessa King is available now.


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John William’s Stoner is the perfect novel. That’s why I read it every year https://harpmaker.net/john-williams-stoner-is-the-perfect-novel-thats-why-i-read-it-every-year/ Sat, 25 Dec 2021 18:00:00 +0000 https://harpmaker.net/john-williams-stoner-is-the-perfect-novel-thats-why-i-read-it-every-year/ I first read the “Perfect Novel” ten years ago. I say the perfect novel because that’s what John Williams’ Stoner is called. When you read this, it will be Boxing Day and I’ll be rereading the novel. That’s what I do every Christmas, I reread Stoner. Plus, I make it a point every year to […]]]>

I first read the “Perfect Novel” ten years ago. I say the perfect novel because that’s what John Williams’ Stoner is called.

When you read this, it will be Boxing Day and I’ll be rereading the novel. That’s what I do every Christmas, I reread Stoner. Plus, I make it a point every year to recommend it to someone or even buy a copy for someone.

It resonates at Christmas. The story of a small life not perfectly but lived without pretension. In this simple way, Stoner affirms life.

William Stoner is the only son of a couple of scrabble farmers. He is brought up in duty and dignity. Words are spared and emotions retained:

“It was an isolated house, of which he was an only child, and it was bound by the necessity of his labor. In the evening, the three of them were sitting in the small kitchen lit by a single kerosene lamp, looking at the yellow. flame; often for the hour or so between supper and bed, the only sound that could be heard was the weary movement of a body in an upright chair and the soft crackle of a wood giving a little less than age. of the House. “

From an early age, he takes care of his household chores. He gets up early, he works hard. He’s a good son. He does what is asked of him. He’s not complaining. He does not dare to dream.

Stoner grows up and to his surprise his father suggests that he go to college to study agriculture and then, armed with new knowledge, return to the family farm. Instead, Stoner falls in love with books and becomes an English teacher.

When he tells his parents that he won’t be coming home, he gently breaks their hearts.

A quiet novel is reborn

William Stoner does not climb very high, he hardly leaves a mark as John Williams writes: “Stoner’s colleagues, who did not particularly esteem him during his lifetime, rarely speak of him now.

Williams, says Stoner, tells us about what’s in store for all of us.

John Williams’ stoner(Provided: Penguin)

Lest I spoil the book, I’ll just say this: The world revolves around Stoner, War, Struggle, Love, Loss and Stoner stays where and who he is.

That’s all.

The word that comes to me is calm. Stoner is a quiet novel.

Maybe that’s why he disappeared with barely a trace on his first outing. It was released as America was on fire in the 1960s.

It couldn’t have been more out of place in an age of riot and revolution, sex, drugs and rock’n’roll.

Then, in a new century, Stoner found its place. A chance review of this lost masterpiece of American literature made it a worldwide bestseller.

It was then that I discovered it and read it on Christmas. He spoke to me like he spoke to so many others exhausted by a world without a pause button. It was what I needed. I had spent too many years as a reporter on the front lines of a world of upheavals, violence, suffering, endless crises from Europe to Africa, to the Middle East, to Asia.

The power of stoicism

It was expensive. I read Stoner at the end of a year in which I had struggled with post-traumatic stress disorder, anxiety, depression. Life had emptied of its meaning. I felt lost. I cut myself off from people, even those closest to me.

Those who loved me helped me through. My own weaknesses prepared me for Stoner. I had to earn the right to read it.

William Stoner endured.

There were times when, reading Stoner, I wanted William to take hold of life, to live recklessly. I wanted him to be impulsive and selfish and put his happiness above all else. But it is this age that speaks where we have declared happiness our right.

I wanted something for him that would only belittle Stoner as a character and diminish the power of the John Williams story. What I wanted for William Stoner would have made it a different and lesser novel.

Stoner speaks of this age as he spoke of the Age of Aquarius when it was written.

William Stoner stays when it’s easier to go. He shows restraint when anger is justified.

If I make him look like an unbearable boredom, it’s because he is in a way. But above all there is stoicism. I don’t have the elegance to capture all the nobility of Stoner’s stoicism.

So I’ll hand it over to John Williams:

“And he would feel that he was out of time … The past has gathered from the darkness where it has remained, and the dead have arisen to live before him; and the past and the dead have flowed into the present among the living, so that he had for an intense moment a vision of density in which he was compacted and from which he could not escape, and had no desire to escape.

Author Steve Almond in his book William Stoner and the Battle for the Inner Life, simply writes: “The dignity of William Stoner makes me feel unworthy.

An antidote to alienation

As Almond points out, Stoner is not a hero as we would know it. Instead, the book “captures with unbearable fidelity the moments of internal turmoil that mark every human life.”

In Stoner, John Williams walks through issues of class, ambition, betrayal, marriage and love… especially love – how we fail and how it fails us. But in the end there is only love.

Stoner is an antidote to a time too dominated by what the philosopher Judith Shklar – drawing on Hegel – called the “unhappy conscience”; “insane”, “wallowed in his own futility”.

Shklar, more than half a century ago, diagnosed this creeping discomfort: “Self-betrayal, helplessness and frustration in the face of an overpowered outside world, such are the conditions of all existence, or at least of life today.

We are not the masters of our own creation but the victims of all that we have not created. “Victimization,” Shklar wrote, “has become a metaphysical category.”

Stoner is a novel from another time about a life in an earlier era. The “perfect novel” does not mean the unblemished novel. In fact, it is far from perfect. It’s imperfect, it’s failed. But isn’t that what brings us back to great works, precisely because they are imperfect as we are imperfect.

Some critics accuse Williams of, at times, caricatural, especially when it comes to wealth and privilege. Others question – quite correctly – its representation of women. It is also a totally white world.

Of course, we can engage in the critical fashion of the day and apply the politics and sensibilities of our time to critique a work from another age.

Or we can sit down with this novel as it is. A story of people each injured in their own way and living with their wounds. The people in John Williams’ novel are, like all of us, to some extent unknown to each other.

“Marriage reveals everything to us”

Basically, it’s a novel about marriage and, as Steve Almond says, “the brutal ways marriage reveals to us all.” In our closest relationships, we are at our best and at our worst.

William Stoner’s wife, Edith, is John Williams’ most complex and compelling character. She reveals Williams’ own limitations, he gives us the literal Edith but even Williams cannot know the Inner Edith. Not like he knows Stoner himself. Ditto for me as a reader.

This marriage is disturbing and for a contemporary reader – as for me – at times deeply disturbing. I understand why some people said they have to put the book down.

William Stoner does not come out virtuous or blameless. It contributes to the pain that he is also suffering from. His indifference is his own cruelty. And then there are moments of tenderness and sweet forgiveness. Just like life.

Since the novel is about William Stoner, the dominant point of view is his. And I agree with Steve Almond, there is a great exhibition of Edith to be written by someone with the depth and humanity to make it.

So why am I reading Stoner? Because of the art of the language, to escape to another time, to be raised and humiliated. Measuring myself against great art demands it. We must remember that life is lived in miniature and not in the great sweep of history. Lives are not artefacts or political statements. History is happening around us but it does not explain to us.

For most of us, in fact, the story is fortuitous. I have reported enough wars and catastrophes to know that daily suffering does not end, in fact it is magnified. People still love, laugh, cry, despair and hope. Together, our little lives fuel our world.

In recent years, we have been trapped in events beyond our control: COVID, China, economic turmoil, death and war. But doesn’t all this remind us that the greatest struggles are waged within us?

Stoner was balm for my hurt soul. I read it every year to remind myself of that time and how near the pain is and how grateful I am that I survived. I come back to it to measure how far I have come and how far I have yet to go. I return there to receive the grace of the inevitable and to know that in passing we will be forgotten in time.

Stoner. I said it was a novel from another time – and I guess that makes it timeless. This is not a fleeting fashion novel. Stoner is a novel of immanence.

Stan Grant presents China Tonight Monday at 9:35 p.m. on ABC TV and Tuesday at 8 p.m. on ABC News Channel.


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Kangwon Land Casino Takes New Approach to Exclusion from Gambling https://harpmaker.net/kangwon-land-casino-takes-new-approach-to-exclusion-from-gambling/ Thu, 23 Dec 2021 17:37:08 +0000 https://harpmaker.net/kangwon-land-casino-takes-new-approach-to-exclusion-from-gambling/ Posted on: Dec 23, 2021, 9:34 a.m. Last update on: December 23, 2021, 9:34 a.m. Kangwon Land in South Korea institutes a new responsible gambling program. It will soon allow a player’s family members to send an email to the casino asking for a 10-day ban to be put in place. Kangwon Land Casino in […]]]>

Posted on: Dec 23, 2021, 9:34 a.m.

Last update on: December 23, 2021, 9:34 a.m.

Kangwon Land in South Korea institutes a new responsible gambling program. It will soon allow a player’s family members to send an email to the casino asking for a 10-day ban to be put in place.

Kangwon Land Casino
Kangwon Land Casino in South Korea is helping players be more responsible. It introduces a new program that will make it easier for family members to request temporary or permanent bans. (Image: Land of Kangwon)

For those who sometimes can’t help themselves and get carried away by their gaming activity, Kangwon Land lends a helping hand. GGRAsia has learned that the only casino in South Korea that accepts locals, as well as foreigners, is launching a new program from January 1. Family members will be able to contact the casino by email or fax to request that a player be banned for 10 days.

A new take on an old problem

The initiative will be available to local and foreign players. It is a way for families to offer responsible gambling measures to their loved ones. An immediate family member, including grandparents, can contact the casino to request the ban. Once contact is established, the ban will take effect immediately.

The 10-day ban is a start and can provide a strong safety net. However, if a player needs a longer timeout, Kangwon Land is also ready. The person will have to provide the necessary documents by mail or during a visit in person and will have to explain the reason for the ban.

That person can choose a one-year, three-year or permanent ban. The latter should only be used in the most serious circumstances since the casino indicates that it cannot be revoked. Kangwon Land staff reviewing the applications will likely also provide feedback before pulling the trigger on the permanent ban.

Kangwon Land helps the community

Previously, family members could request a ban, but only by going to the casino. With COVID-19 issues being what they are, some people are less willing to venture out. Plus, the ability to email or fax a request almost adds a sense of anonymity. This could allow contact with the casino for a ban when someone might not otherwise be so willing.

The person GGRAsia spoke to at the casino said 55 people were banned in the first seven months of this year. This is a relatively small number, but traffic to the casino has been drastically reduced over the period.

The number of daily visitors allowed to the casino was increased in early November from 1,800 to 2,300. That figure was later increased to 3,000. However, a resurgence of COVID-19 in South Korea has caused a further slowdown.

From December 18, Kangwon Land reduced its hours of operation, only operating from 10:00 a.m. to 10:00 p.m. daily. The new policy will be in place at least until January 2.

The casino, about three hours from Seoul, has seen several stops and starts. The third quarter of the year came to a standstill, with a net profit of KRW 20.42 billion (US $ 17.2 million). This is a decrease of 2.4% from the previous quarter.


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Are these curtains for the chemo? https://harpmaker.net/are-these-curtains-for-the-chemo/ Tue, 21 Dec 2021 20:45:40 +0000 https://harpmaker.net/are-these-curtains-for-the-chemo/ ATLANTA, Georgia – Chemotherapy has been the mainstay of treatment for adults with acute lymphoblastic leukemia (ALL) for many decades, but new approaches are now emerging. Results with new therapies – including antibody-drug conjugates and chimeric antigen receptor (CAR) T cell therapies – as well as tyrosine kinase inhibitors have led one expert to question […]]]>

ATLANTA, Georgia – Chemotherapy has been the mainstay of treatment for adults with acute lymphoblastic leukemia (ALL) for many decades, but new approaches are now emerging.

Results with new therapies – including antibody-drug conjugates and chimeric antigen receptor (CAR) T cell therapies – as well as tyrosine kinase inhibitors have led one expert to question whether it is time for a “curtain call for conventional chemotherapy” in older adults with ALL.

Although a more appropriate question may be, “Are these curtains for chemotherapy?” The question was asked by Marlise Luskin, MD, MSCE, of the Dana-Farber Cancer Institute in Boston, Massachusetts, who was speaking in an educational session here at the 2021 annual meeting of the American Society of Hematology.

The session focused on how best to use these new approaches to improve the survival of older people with ALL.

“Today, in 2021, as a result of decades of collaborative research, the vast majority of children in resourced medical centers are cured of ALL,” Luskin told the audience.

“However, half of ALL diagnoses occur in adults, with about half of these being in patients over the age of about 50 or 60,” she noted.

“Even adults who are fit enough for treatment with intensive chemotherapy regimens have lower results than [those for] their pediatric counterparts, and although young adults have seen their results improve when treated on pediatric-inspired regimens, most adults in 2021 are not cured of their disease, ”she said. commented.

Currently approved agents for the treatment of relapsed / refractory ALL-B include the bi-specific T cell activator blinatumomab (Blincyto) and the antibody-drug conjugate inotuzumab ozogamicin (Bespona).

In addition, venetoclax (Venclexta), a selective inhibitor of Bcl-2, is currently under investigation for this indication.

There is also CAR-T cell therapy tisagenlecleucel (Kymriah) although the approved indication specifies that it is for use in r / r ALL in adults under 25 years of age.

Early experience with blinatumomab and inotuzumab in older people with Ph-ALL has demonstrated high response rates and low early mortality, although longer-term efficacy and safety data are available. still needed, Luskin commented.

Also in this elderly population with Ph-positive ALL (Ph + ALL), tyrosine kinase inhibitors (TKIs) have revolutionized care and made it possible to reduce or omit conventional chemotherapy, she said.

The two approaches are also being tried in combination: a new study presented at the meeting reported good results in older people with ALL with a combination of blinatumomab with the TKI dasatinib (Sprycel).

“Historically this subtype (Ph + ALL) has had an unfavorable prognosis, but in the era of TKI outcomes have improved for patients of all ages, and is now considered in the older population to be equivalent otherwise better than patients with Ph-negative ALL, because TKIs alone in combination with steroids can induce remissions in a significant number of patients and allowed the reduction or omission of conventional chemotherapy at the start of treatment, this which has been particularly beneficial for older patients, ”said Luskin.

There is still room for improvement in results, however, and it is still unclear which TKIs are best, which combinations of TKIs with other agents provide the best efficacy, and whether chemotherapy still has a role in these. patients, she added.

However, treatment options for patients with T-cell-induced ALL are still lacking, Luskin pointed out.

Achieve MRD negativity

Another leukemia specialist discussed how to help adults with ALL achieve minimal residual disease negativity (MRD).

Nikola Gökbuget, MD, from Goethe University Hospital in Frankfurt, Germany, began his presentation by discussing the definition of MRD.

A widely accepted definition of MRD is the presence of residual blast cells below the cytology limit of detection, which is approximately 5%.

“When we talk about treatment decisions based on MRD, we usually think of the first line of treatment, and in this situation measuring the MRD shows us the individual response to standard first-line chemotherapy regimens. However, MRD is also gaining importance as an indication. the effectiveness of the new compounds, ”she said.

The essentials for the assessment of MRD by any method include good primary diagnostic materials and expert laboratory services that adhere to international benchmarks, she said.

MRD tests have a higher sensitivity to detect B-precursor ALL in bone marrow than in peripheral blood, although peripheral blood is suitable for follow-up testing for T-cell ALL, she said.

The German multicenter ALL group (GMALL) defines complete molecular remissions (CR) as MRD negativity with a sensitivity of 10-4 or less, and molecular failure as MRD positivity as anything above that threshold of 10-4 . There are also categories of molecular intermediates: positive MRD less than 10-4, non-evaluable MRD and molecular relapse after previous molecular CR.

Factors of MRD that can affect treatment decisions include the level of MRD and when it occurs, as well as the subtype and prognostic indications of the various characteristics. Higher degrees of MRM, as well as the persistence of MRM later in treatment, are both generally prognostic for worse outcomes, she noted.

Treatment options based on the results of MRD for patients with poor initial responses include intensification of chemotherapy and possible allogeneic stem cell transplantation, as well as the use of new target approaches to eradicate MRD.

CAR T or new therapies?

Noelle V. Frey, MD, MS, of the University of Pennsylvania, Philadelphia, discussed whether to use CAR T cell therapy or one of the newer agents.

“There are several things to consider when choosing between CAR T cell therapy and other potential therapies,” Frey said. “The first, of course, is whether this is a feasible option for your patients. If they live near a tertiary care center, access is now less of a concern given the availability of commercial products for pediatrics and adults. “

“The question then becomes whether it is clinically feasible? Is there a clinical and logistical window for pheresis, and is there a realistic transition plan based on your patient’s disease burden and treatment history? She continued.

CAR T cell therapy is associated with CR rates ranging from 62% to 93% in heavily pretreated patients, and the remissions it induces are rapid. Long-lasting remissions are possible, although they vary by product, she said.

“When considering the potential benefit of CAR T cells over other products, it is essential to take into account the patient’s transplant history: are they relapsing after an allogeneic transplant? Frey said.

Toxicities with CAR T cells – including cytokine release syndrome (CRS) and associated immune effector cells neurotoxicity (ICANS) – vary depending on CAR T concept used, disease burden, patient age and co-morbidities. These considerations will be taken into account when choosing between CAR T therapy and other initial treatment options, such as blinatumomab and inotuzumab, Frey said.

CAR T therapy can serve as a successful gateway to an allogeneic transplant, but CAR T on its own is able to induce lasting remissions, so the question becomes “to transition or not?” Frey said more data is needed to conclusively answer this question.

What about the transplant?

During the question-and-answer session, Bryan D. Huber, MD, of Intermountain Healthcare in Salt Lake City, Utah, asked if an initial transplant should be considered in older, fit adults with Ph + ALL.

“I think that’s a great question with no easy answer,” Luskin replied. “As I approach older people with Ph + ALL, what encourages me is that many patients with the ability for TKIs and the incorporation of new agents as well as the ability to sequence TKIs often get deep and very long remissions. Although cure may not be possible in these situations, these remissions can last for years, and for patients who may have high toxicity or who may not be doing well with the transplant, the transplant may not be the right option. “

She also recognized that there is a range of fitness levels in the elderly, “and I think very carefully about whether a patient is likely to do well with a transplant before referring him or her, given that he now has very good treatment options “.

Gökbuget disclosed speaker fees, travel assistance, and advisory board participations for several companies. Frey disclosed Novartis research funding and advice to others. Luskin and Huber did not disclose any relevant financial relationship.

American Society of Hematology 63rd Annual Meeting and Exhibition: Education Session. Presented on December 11, 2021.

Award-winning medical journalist Neil Osterweil is a long-time and frequent contributor to Medscape.

For more news, follow Medscape on Facebook, Twitter, Instagram, and Youtube.



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New government strategy makes solar and wind monitoring data public for the first time – pv magazine Australia https://harpmaker.net/new-government-strategy-makes-solar-and-wind-monitoring-data-public-for-the-first-time-pv-magazine-australia/ Sun, 19 Dec 2021 23:10:18 +0000 https://harpmaker.net/new-government-strategy-makes-solar-and-wind-monitoring-data-public-for-the-first-time-pv-magazine-australia/ In an unconventional attempt to attract large-scale renewable developments, the Queensland government has arranged for generally highly confidential solar and wind monitoring data to be made public for the first time through Fulcrum’s technology platforms. 3d. 20 December 2021 peacock bella Economic Development Queensland is working with Australian resource monitoring company Fulcrum3D to, for the […]]]>

In an unconventional attempt to attract large-scale renewable developments, the Queensland government has arranged for generally highly confidential solar and wind monitoring data to be made public for the first time through Fulcrum’s technology platforms. 3d.

Economic Development Queensland is working with Australian resource monitoring company Fulcrum3D to, for the first time, release data on solar and wind resources as part of a strategy to encourage the development of large-scale renewable energy in the north Queensland coast. Specifically, the government wants to see its 6,355 hectares of freehold land at Abbot Point, just north of Bowen, transformed by major projects to become the Salisbury Plains industrial area.

The technological partner of the project is Fulcrum3D and uses their flagship portable monitoring unit Sodar, equipped with additional pyranometers, with this data made available thanks to its 24-hour FlightDECK data management system.

“We have been monitoring the downloads and they are certainly viewed and viewed multiple times,” said Fulcrum3D Founder and CEO Colin Bonner. pv magazine Australia.

“From our perspective, it’s fantastic to see proactive government strategy and policies,” he said. “It’s sort of the lifeblood of the industry,” Bonner added, noting that in the 10 years since its founding, corporate governments have tended to be quite slow on policy reform. and adoption of renewable energies.

While the 24-month program is still ongoing (data monitoring began in November 2020), Bonner said so far it has shown “high potential” for wind and solar projects.

Technology

Fulcrum3D’s Sodar product launched the company in 2011 and works much like sonar on a submarine, diffusing the sound of thermal turbulence into the atmosphere by a pulse sent every two seconds.

With the rise of wind-solar colocation, Bonner said most developers are also opting to add a few pyranometers to monitor solar irradiance on-site, with the company using Germany’s Kipp & Zonen’s SMP11.

Fulcrum3D Sodar Unit

Fulcrum3D

“The object of the game here is to reduce [yield] uncertain, ”Bonner said. He noted that there are all kinds of ways to collect solar irradiation data, with satellite data typically having a margin of error of between 5% and 10%. Using an on-site pyranometer reduces this uncertainty to between 3% and 5%.

Each of the Sodar units collects 5 GB to 10 GB of data each month, with a large part of the Fulcrum3D offer and then the cyber infrastructure that manages these huge data sets.

This data is generally very confidential, of course, and is only seen by the developers and their technical consultancies. This is the first time the company has worked with a government to make it public – although Bonner said it likely won’t be the last.

The model is attracting government interest

“We are in talks with other ministries in different states,” he said, although he was unable to give more details on who they were precisely. “But certainly other government agencies [are] explore a model to demonstrate that the land they manage or access has good resources.

He described the Salisbury Plains project as a great opportunity. “Because it’s the government and they already have land rights, they’re trying to attract developers to this area. So it’s in their best interest to make it public… it’s almost relying on the ethics of renewable energy zones where they try to encourage developers to work together to have a more efficient process.

Queensland Economic Development has not been able to give pv magazine no indication as to whether their strategy has attracted developers to date, classifying the information as sensitive.

This content is protected by copyright and cannot be reused. If you would like to cooperate with us and would like to reuse some of our content, please contact: editors@pv-magazine.com.


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Concise, moving novel about abuse at Irish Catholic laundries asks eerily familiar questions https://harpmaker.net/concise-moving-novel-about-abuse-at-irish-catholic-laundries-asks-eerily-familiar-questions/ Sat, 18 Dec 2021 08:00:07 +0000 https://harpmaker.net/concise-moving-novel-about-abuse-at-irish-catholic-laundries-asks-eerily-familiar-questions/ This striking debut novel comes from the Emerald Isle, but covers a subject with eerie parallels to Canadian history. Little things like these explores an ordinary man’s discovery of abuse in a respected institution and his decision on how to respond to it. Murdo MacLeod Irish author Claire Keegan… TK “/> Murdo MacLeod Irish author […]]]>



This striking debut novel comes from the Emerald Isle, but covers a subject with eerie parallels to Canadian history.

Little things like these explores an ordinary man’s discovery of abuse in a respected institution and his decision on how to respond to it.

Murdo MacLeod

Irish author Claire Keegan… TK

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Murdo MacLeod

Irish author Claire Keegan… TK

Author Claire Keegan examines themes of guilt, complacency, abuse of power, and service to others.

The novel will introduce many readers to the shameful laundries of the Madeleine in Ireland. Managed by the Catholic Church, these laundries presented themselves as refuges for so-called fallen women.

In reality, the detainees were locked inside, given different names and hungry. Children of detainees were separated from their mothers and adopted without their consent.

Seems familiar?



<p>Little things like these</p>
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						</a><figcaption>
<p>Little things like these</p>
</figcaption></figure>
<p>The story begins in rural Ireland, 1985. The main character Bill Furlong opens the story, which is told in the third person from his point of view.			</p>
<p>Bill immediately shows himself as a good man who works hard and loves his family.			</p>
<p>He knows he is fortunate enough to own a stable business during a time of high unemployment and is humble enough to admit his good fortune without dominating it over others:?  Times were tough but Furlong felt all the more determined to keep going, to keep his head down and stay on the good side of people, and to continue providing for his daughters, to see them continue and finish their education at St Margaret ?? s, the only good girls’ school in town.?  ?			</p>
<p>As Christmas approaches, Bill delivers a load of charcoal to the convent which manages the Sainte-Marguerite school.  He accidentally enters a scene that alarms him and makes him question what little he knows about the convent.			</p>
<p>Bill might ignore what he’s learned, but isn’t he sure he can live with the decision.  what was there and yet call you a christian, and face you in the mirror ???  he says to him.			</p>
<p>But to speak of what he saw is to risk his safety and that of his family.			</p>
<p>As he wonders what to do, Bill learns how many others are willing to be silent and how difficult it is to blame a Higher Power.			</p>
<p>Keegan has perfected his writing on short stories, and those roots are found in this beautifully crafted novel.  She chooses every word deliberately, wasting no time in elaborate descriptions or dialogue.			</p>
<p>His skill at telling a vibrant story in as few words as possible may remind readers of fellow Irish novelist Colm Tóibín, best known for his 2010 novel. <em>Brooklyn </em>(adapted in film in 2015.)			</p>
<div class=

Keegan keeps the story outside of the convent itself. Readers see the abuse through Bill’s eyes ?? not much, but enough to know that something was wrong.

Other people reveal their characters when they react to Bill’s argument at the convent.

A restaurant owner warns Bill not to risk his business by exposing the convent, using the phrase “keep the bad dog with you and the good dog won’t bite.”

Bill’s wife chooses to blame the inmates, noting that “all their people did was leave them wild and then when they got in trouble they turned their backs.

Little things like these isn’t your typical Christmas book, but it gets to the heart of the Christmas message: caring for others and bringing light to dark times.

Kathryne Cardwell is a writer from Winnipeg.

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