Novel – Harp Maker http://harpmaker.net/ Thu, 30 Jun 2022 12:27:48 +0000 en-US hourly 1 https://wordpress.org/?v=5.9.3 https://harpmaker.net/wp-content/uploads/2021/06/cropped-icon-32x32.png Novel – Harp Maker http://harpmaker.net/ 32 32 Inceptor Bio announces a strategic collaboration with the University of Minnesota to develop a novel iPSC platform for the advancement of next-generation allogeneic cell therapies https://harpmaker.net/inceptor-bio-announces-a-strategic-collaboration-with-the-university-of-minnesota-to-develop-a-novel-ipsc-platform-for-the-advancement-of-next-generation-allogeneic-cell-therapies/ Thu, 30 Jun 2022 12:00:00 +0000 https://harpmaker.net/inceptor-bio-announces-a-strategic-collaboration-with-the-university-of-minnesota-to-develop-a-novel-ipsc-platform-for-the-advancement-of-next-generation-allogeneic-cell-therapies/ MORRISVILLE, North Carolina, June 30, 2022 /PRNewswire/ — Inceptor Bio, a biotechnology company advancing cell therapies for hard-to-treat cancers, today announced a collaboration with University of Minnesota. The goal of this collaboration is to build a novel induced pluripotent stem cell (iPSC) platform that will accelerate Inceptor Bio’s leading next-generation cell therapy platforms. Under the […]]]>

MORRISVILLE, North Carolina, June 30, 2022 /PRNewswire/ — Inceptor Bio, a biotechnology company advancing cell therapies for hard-to-treat cancers, today announced a collaboration with University of Minnesota. The goal of this collaboration is to build a novel induced pluripotent stem cell (iPSC) platform that will accelerate Inceptor Bio’s leading next-generation cell therapy platforms. Under the terms of the agreement, Inceptor Bio will receive an exclusive license to the technology developed through this collaboration.

(PRNewsfoto/Inceptor Bio)

Inceptor Bio plans to advance several cell therapy products into clinical studies integrating the iPSC platform into its proprietary K62 platform for CAR-M therapy, which increases the phagocytic abilities of macrophages and supports an anti- tumor M1, as well as its new stimulation co-domain, M83, for CAR-NK therapies.

“iPSC-derived cell therapies have the potential to unlock the next frontier in cell therapies. We are excited to work with Dr. Handsome Webber at University of Minnesota and his team to develop this unique platform,” said Mike NicholsonPh.D., President and COO of Inceptor Bio.

“The team of University of Minnesota is confident that Inceptor Bio is the right partner to build a differentiated iPSC platform to advance novel cell therapies,” said Beau Webber, Ph.D., assistant professor in the Department of Pediatrics, Division of Hematology and ‘oncology. “We are deeply encouraged by Inceptor Bio’s advances in cell therapy, and we look forward to being part of future developments to help cure hard-to-treat cancers.” »

“This partnership is an important step in continuing to execute on our strategy to advance cell therapies to provide a more positive prognosis and quality of life for patients with difficult-to-treat cancers,” said Abe Maingi, Vice President, Business Development at Inceptor Bio. “We are excited to be able to develop and deliver on the promise of iPSC-derived cell therapies.”

About Inceptor Bio

Inceptor Bio is a biotechnology company developing several next-generation cell therapy platforms to deliver cures for underserved and hard-to-treat cancers. Inceptor Bio builds platforms in CAR-T, CAR-M and CAR-NK. Inceptor Bio is headquartered in Morrisville, North Carolina. More information is available at www.inceptor.bio.

Media Contact
Abe Maingi
abe.maingi@inceptor.bio

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SOURCE Inceptor

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Swing Therapeutics Selects Curavit to Provide Virtual Trial Site Services for New Digital Fibromyalgia Therapeutics Study https://harpmaker.net/swing-therapeutics-selects-curavit-to-provide-virtual-trial-site-services-for-new-digital-fibromyalgia-therapeutics-study/ Tue, 28 Jun 2022 12:00:00 +0000 https://harpmaker.net/swing-therapeutics-selects-curavit-to-provide-virtual-trial-site-services-for-new-digital-fibromyalgia-therapeutics-study/ BOSTON, June 28, 2022 /PRNewswire/ — Curavit clinical research, a virtual contract research organization (VCRO), has been selected by a digital therapy company, Therapeutic Swing, to be a virtual site for its pivotal trial of an experimental digital therapy (DTx) for fibromyalgia. Curavit will remotely recruit, screen, consent and enroll Swing’s participants PROSPER-FM randomized clinical […]]]>

BOSTON, June 28, 2022 /PRNewswire/ — Curavit clinical research, a virtual contract research organization (VCRO), has been selected by a digital therapy company, Therapeutic Swing, to be a virtual site for its pivotal trial of an experimental digital therapy (DTx) for fibromyalgia. Curavit will remotely recruit, screen, consent and enroll Swing’s participants PROSPER-FM randomized clinical trial through United States. Curavit will then manage participants throughout the 12-week clinical trial. By removing physical and geographic barriers to trial participation and execution, Curavit can scale rapidly and improve patient recruitment by at least 10x compared to a traditional trial, thereby accelerating trial execution.

Fibromyalgia is a chronic, debilitating pain that affects more than 10 million Americans. It is characterized by generalized musculoskeletal pain often accompanied by fatigue, sleep disturbances, memory and mood. Swing developed its digital therapy with the goal of providing an accessible behavioral therapy option that can be used alongside medication, physical therapy, and other standard treatments.

“We are focused on good patient recruitment,” said Mike RosenbluthPhD, Chief Executive Officer of Swing, who recently announcement a $10M Series A funding round. “Curavit’s virtual service model allows us to effectively recruit participants representative of the entire patient population. It solves a huge challenge and will be key to rapidly building the evidence needed to bring effective digital therapy to millions of people with chronic conditions.

Swing marks the 10 of Curavite DTx client signed in less than six months, trending in line with booming global DTx market expected to reach $13.1 billion by 2026from $3.4 billion in 2021. Curavit’s decentralized clinical trial (DCT) expertise makes the company well-suited to support prescription and non-prescription DTx studies. Basically, there are no physical logistics with a DTx – no shipping, storage, chain of custody, cold storage or biohazards, and endpoints can often be captured in the DTx app itself, naturally aligning DCTs with DTx studies.

“Swing is committed to developing scientifically backed digital treatments and evidence to clinically validate their use in the real world, making representative patient engagement essential,” said Joel Morse, co-founder and CEO of Curavit. “Our operating model prioritizes patient recruitment and removes geographic boundaries to expand the pool without the expense of physical infrastructure. With zero physical visits to site as well, patients are less overburdened and more likely to stick on trial for the duration.”

About Curavit

Curavit clinical research is a full-service virtual contract research organization (VCRO) focused on the design and execution of digital decentralized clinical trials (DCTs). Founded in 2020 by experts with decades of experience in technology and clinical research, Curavit leverages emerging technologies in digital health, cloud computing and data science to recruit, engage and monitor diverse populations patients without borders and offer trials to patients in the cloud. . Curavit’s first digital DCTs improve timelines, reduce costs, generate real data and increase patient access to more effective therapies in representative populations. Visit www.curavitclinicalresearch.com.

SOURCE Curavit Clinical Research

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Arkham Asylum introduced a new villain that readers won’t see https://harpmaker.net/arkham-asylum-introduced-a-new-villain-that-readers-wont-see/ Sun, 26 Jun 2022 19:56:18 +0000 https://harpmaker.net/arkham-asylum-introduced-a-new-villain-that-readers-wont-see/ Written by Grant Morrison and illustrated by Dave McKean, 1989 Arkham Asylum: A Serious House on Serious Land hit the comics industry like an electric shock when it was released. Despite its arthouse sensibilities, a mainstream audience has emerged to champion its experimental visuals, layered writing, and truly bizarre take on the Batman mythos. Everything […]]]>

Written by Grant Morrison and illustrated by Dave McKean, 1989 Arkham Asylum: A Serious House on Serious Land hit the comics industry like an electric shock when it was released. Despite its arthouse sensibilities, a mainstream audience has emerged to champion its experimental visuals, layered writing, and truly bizarre take on the Batman mythos. Everything from the Arkham series of video games to Christopher Nolan The black Knight the movie trilogy owes at least some debt to the graphic novel.


At one point, arkham asylum was the best-selling graphic novel in history and has now sold over 600,000 copies. Despite this, the book was dismissed by some reviewers as unnecessarily pretentious and impossible to penetrate. The book’s esoteric visuals are sometimes so hostile to the audience that there turns out to be an Arkham inmate in the script virtually invisible to the naked eye.

Related: The “Secret” Crossover Between Batman And Daredevil

A breathtaking asylum epic

A simple plot summary hardly hints at the unusual presentation of the graphic novel. On the surface, arkham asylum is the story of Batman receiving a call on April Fool’s Day to deal with a riot within Arkham Asylum. The staff have been taken hostage, and the Joker demands that Batman arrive to free them. Once inside, Batman has one-on-one skirmishes with characters from his traditional rogues gallery, Joker, Two-Face, Maxie Zeus, Clayface, Mad Hatter, and Killer Croc. Penetrating deeper into the asylum, Batman stumbles upon a dark secret that haunts the mansion.


However, readers expecting something resembling the monthly Batman the titles came as a surprise upon opening the book and finding McKean’s frenetic paintings and multimedia collages paired with Morrison’s seemingly chaotic narrative. It used to be the material only found in basements and it was unlikely to be presented with such superior production values.

The graphic novel’s reputation inspired DC to re-release arkham asylum periodically, meaning Morrison’s original script and layouts were presented to the public for the first time as ancillary material in the Anniversary Collections. Visually, arkham asylum is iconic, thanks to its portrayal of a Batman who is more of a shadow than a man, surreal page designs, and the innovative technique of designing unique word bubbles for each main character. What his detractors also noted, however, was that parts of the narrative were impossible to understand.


Morrison’s original script and annotations greatly demystify the work. In fact, they reveal intricacies in the narrative that you wouldn’t truly grasp unless you had direct access to Morrison’s brain. The clownfish’s gendered qualities, Batman’s stunted fear of his own sexuality, symbolized by a vision of a carnival’s “Tunnel of Love” attraction, Clayface as a visual representation of 1980s AIDS anxieties, the meaning visual of Batman skewering Killer Croc as an analog for the spear that impaled Christ…these are themes a layman probably won’t notice without the annotations.


Related: The Flash Family May Have Won A Bat-Flash

A good story based on a bad day

This additional material reveals the liberties McKean took when viewing Morrison’s plot. In Grant Morrison: Combining the Worlds of Contemporary Comicssays Morrison, “I imagined [Arkham Asylum] to be done by someone like Brian Bolland, and my vision was that it was ultra-real to the point of being painful… But when Dave McKean did it, it became something entirely different, because that he wanted to make it more abstract. And I think in a lot of ways the ways that we approached it collided in the middle…I think it would have been easier for people to deal with if it had been a lot more concrete.


Given Bolland’s success with the 1988s Batman: The Killing Joke (associated with writer Alan Moore), it’s no surprise that Morrison had Bolland in mind when crafting the story. Bolland’s meticulous and highly detailed art, coupled with Moore’s pessimistic account of the “bad day” that spawned the Joker madness, left readers at the time bewildered. The book was controversial upon release, but also a sales giant, encouraging DC to pursue more adult-oriented stories featuring Batman. arkham asylum probably couldn’t have fit into Bolland’s program, but a Morrison/Bolland arkham asylum wouldn’t have been too impossible to imagine around 1988.

McKean has been open about his antipathy towards American superheroes and what he perceives as the industry’s rigid and “very overpainted” aesthetic in the past. In the years following the release of arkham asylum (as archived by Sequart), he said he was “trying to do the book despite the subject matter, rather than because of it. Ultimately, if you really love making Batman comics, then this is probably the best thing to Not liking them, and then trying to make something out of them is just a waste of time.” McKean’s dislike of colorful superheroes led him to flatly refuse to draw Robin, although Morrison at one point attempted to compromise and keep the Boy Wonder in a trench coat.


Related: The Latest Superman/Batman Fusion Is Wild And Straight Out Of Dragon Ball Z

How a Departed Character Influences the Story of Arkham Asylum

Behind Morrison’s notes is another concept obscured by McKean’s art. He’s a brand new character that most readers never noticed! Morrison’s screenplay describes a “huge man with a shaved head” sitting in the asylum’s dining room, watching television. “He looks abnormal, inbred. Saliva drips down his weak chin. He smiles weakly, stupidly, clutching a rag doll to his chest. This guy is a killer named Bambi. His name is not mentioned, but he comes back later.” Morrison’s annotations indicate that an earlier draft had Bambi physically attacking Batman after he entered.

Finding a huge, bald man watching TV in McKean’s rendered double-page spread is… difficult. The last panel is McKean’s depiction of Bambi looking psychology.

Christening a murderous psychopath “Bambi” may initially seem like dark humor on Morrison’s part (perhaps even an inside joke, since the script says he will remain nameless), but the name represents a much bigger theme. deep. “Who killed Bambi? a floating word balloon asks as Batman enters the asylum, sparking pop culture memories of the Disney film (which was based on German novelist Felix Salten Bambi, a life in the woods.) Although classic Disney movies are often mocked for cleaning up their source material, 1942’s Bambi features a famous sequence with Bambi’s mother being shot by a hunter, a scene that has upset countless children over the years.


The Wrinkle in Batman’s Origin Story Found in arkham asylum will the Wayne family see first Bambi to the theatre, then departure for a performance of Zorro In place. They go out Bambi because Bruce is traumatized by the on-screen death of Bambi’s mother, used here by Morrison as foreshadowing the impending death of Bruce’s mother.

The Bambi of arkham asylum watch the Alfred Hitchcock movie psychology on the hospital television set, introducing another link between this story and popular cinema. Morrison intended to play the deceased mothers of Bambi and psychology against Batman’s traumatic memory of his mother’s murder. (While also subverting the usual portrayal of Bruce’s trauma, which tends to focus more on his father, Thomas.) The occasional quotes from psychology who appear throughout the story are meant to be Bambi watching the movie on TV, though the visuals don’t make it clear at all.

Morrison’s intent is lost without an actual character rendered on the panel, staring at a TV with psychology On the screen. Based on the printed pages alone, it’s hard to discern that Bambi even exists. And given DC’s tendency to exploit its past, it also means audiences never saw Bambi’s likely return in monthly comic book titles, the Animated series cameo and boss fights in the Arkham Games. Maybe the next arkham asylum birthday – like the 35th, which will arrive in 2024 – will finally give Bambi his due.

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Novel Therapeutic Delivery Routes for the Management of PD OFF Episodes https://harpmaker.net/novel-therapeutic-delivery-routes-for-the-management-of-pd-off-episodes/ Thu, 23 Jun 2022 03:54:13 +0000 https://harpmaker.net/novel-therapeutic-delivery-routes-for-the-management-of-pd-off-episodes/ Stuart Isaacson, MD: Let’s talk about this gap. You bring an interesting perspective on future directions for handling OFF episodes. Bob, you have participated in many programs. You mentioned earlier if we could have a twice-daily oral route, or if we could have a robust, well-tolerated transdermal route. Continuous infusions are examined. Where do you […]]]>

Stuart Isaacson, MD: Let’s talk about this gap. You bring an interesting perspective on future directions for handling OFF episodes. Bob, you have participated in many programs. You mentioned earlier if we could have a twice-daily oral route, or if we could have a robust, well-tolerated transdermal route. Continuous infusions are examined. Where do you think this is heading? Do you think we need a new route of administration or a sophisticated long-acting oral drug? What do you think are the pathways if patients have been on a lot of these drug classes, as described by Raj? We have on-demand therapies, but we need to make sure they do it right. They do not want to undergo surgical treatments, either in the skull or in the abdomen. Where do you think this is heading?

Robert A. Hauser, MD, MBA: There will be ongoing efforts to find a very long-acting oral formulation of carbidopa-levodopa. There is a longer acting carbidopa-levodopa formulation in development called IPX203. The results have just been made public, which seems encouraging. It’s definitely not once or twice a day therapy. Most people might need it 3 or 4 times a day, but efforts will continue to be made to figure out how to get closer to a twice-daily oral. It looks very appealing to me. This is how most medications are administered. If a manufacturer could offer this, that would be ideal.

The other route that is getting a lot of attention is subcutaneous infusion. In development, there is a subcutaneous infusion of carbidopa-levodopa, plus another version of another manufacturer’s, as well as apomorphine for subcutaneous infusions. These will definitely hit the market. They have limitations related to a delivery system and the drugs themselves. They will try, as much as possible, to bridge the gap between our oral medications and device-assisted therapies or surgery.

Stuart Isaacson, MD: Raj, do you think these subcutaneous infusions will be additional advanced therapies? Or do you think they will fill an intermediate role somewhere between oral and surgical options?

Rajesh Pahwa, MD: They will bridge that gap between intermediate and surgical therapies with what we will eventually call these pump therapies. The only thing is that we cannot call them pump therapies because carbidopa-levodopa and enteral suspension are also given by pump. We have patients in whom we have tried complementary therapies and in whom we have given therapies on demand. Either they are not ready for surgery or their symptoms are not severe enough to require surgery, but they still have an OFF time. Even starting a subcutaneous levodopa infusion using subcutaneous apomorphine infusion can give them enough ON time without requiring brain stimulation or carbidopa-levodopa enteral suspension, all of which require two surgery to access this therapy. This is an unmet need that, in the near future, we could help our patients fill. I am very excited about this therapy, which will hopefully be available soon.

Transcript edited for clarity

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New synthetic polymers could lead to better crop yields for farmers https://harpmaker.net/new-synthetic-polymers-could-lead-to-better-crop-yields-for-farmers/ Tue, 21 Jun 2022 08:00:02 +0000 https://harpmaker.net/new-synthetic-polymers-could-lead-to-better-crop-yields-for-farmers/ Credit: Unsplash/CC0 public domain Scientists at the University of Birmingham have invented a new method to encourage bacteria to form growth-promoting ecosystems that could be used to coat the roots of plant seedlings, which should result in stronger, healthier plants and higher crop yields in agriculture. In nature, the roots of seedlings form mutually beneficial […]]]>

Credit: Unsplash/CC0 public domain

Scientists at the University of Birmingham have invented a new method to encourage bacteria to form growth-promoting ecosystems that could be used to coat the roots of plant seedlings, which should result in stronger, healthier plants and higher crop yields in agriculture.

In nature, the roots of seedlings form mutually beneficial relationships with communities of microbes (fungi, bacteria, viruses) in the soil and exchange nutrients, allowing both the plant and the microbes to thrive. This is especially critical in the early stages of a plant’s life when the seedling is in a race against time to achieve self-sustaining growth before the seed’s nutrients and energy reserves are depleted.

Dr. Tim Overton, an applied microbiologist from the University’s School of Chemical Engineering, and Dr. Francisco Fernandez-Trillo from the School of Chemistry led a team to develop new synthetic polymers that stimulate the formation of these bacterial communities in a way that mirrors a natural process known as biofilm formation.

A biofilm is a finely orchestrated community of microbes supported by a matrix of biological polymers that forms a protective microenvironment and holds the community together.

The researchers worked together on a four-year project on how polymers interact with bacteria, which resulted in the synthesis of a group of acylhydrazone-based polymers.

These novel polymers were designed to act as an adhesive scaffold, “seeding” the formation of a microorganism-polymer complex to initiate and accelerate biofilm formation. Once the biofilm is formed, the bacteria become a self-sufficient and self-organizing community, and produce their own matrix to allow the transmission of nutrients and water, and the evacuation of wastes.

The project involved a Ph.D. students Pavan Adoni and Omar Huneidi, who went on to advance research showing that polymers aggregate bacteria and enhance biofilm formation. Critically, they also showed that the process is fully reversible and that biofilm can be dispersed by changing environmental conditions. The results of these experiments and other studies will be published in 2022.

Pavan Adoni commented: “We anticipate that the polymer will eventually be used as a seed coating, perhaps in conjunction with bacteria such as B. Subtilis, which is naturally present in soil, increases plant stress tolerance and is currently used as a soil inoculant. We envision a more targeted approach that only treats the seed, so that when it germinates, the bacteria are ready to grow in the safe environment provided by a polymer complex of microorganisms. Ultimately, this should result in stronger plants that grow faster. , and have greater resistance to disease.”

The University of Birmingham Enterprise has filed a broad patent application covering the novel polymers, the method of biofilm formation and the method of polymer cleavage, and its use to promote biofilm growth with any microorganism, including including those who can produce or deliver chemicals. or biological molecules.

The patent has now been licensed to life sciences company PBL Technology, which invests in, protects and promotes emerging innovations from public research sources around the world. In agriculture, PBL’s technologies include crop genetics, crop treatments, precision agriculture, and R&D promoters and tools.


Researchers propose a new strategy for the prevention and treatment of dental caries


Provided by University of Birmingham


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Light Of The Moon Publishing Releases New GW Mullins Novel “Rise Of The Snow Queen Book Three: The Story Of Gerda And Kai” https://harpmaker.net/light-of-the-moon-publishing-releases-new-gw-mullins-novel-rise-of-the-snow-queen-book-three-the-story-of-gerda-and-kai/ Sun, 19 Jun 2022 07:00:00 +0000 https://harpmaker.net/light-of-the-moon-publishing-releases-new-gw-mullins-novel-rise-of-the-snow-queen-book-three-the-story-of-gerda-and-kai/ New York, NY, June 19, 2022 — (PR.com) — Best-selling author GW Mullins adds a new volume to his highly successful adult dark fantasy “Rise Of The Snow Queen” with the third of a four -part series. What begins as a simple, bittersweet story about a man transformed into a polar bear, unfolds grandly into […]]]>
New York, NY, June 19, 2022 — (PR.com) — Best-selling author GW Mullins adds a new volume to his highly successful adult dark fantasy “Rise Of The Snow Queen” with the third of a four -part series. What begins as a simple, bittersweet story about a man transformed into a polar bear, unfolds grandly into a rich, mythical adventure in the Rise Of The Snow Queen book series. Based on Hans Christian Andersen’s fairy tale, author GW Mullins expands on this story by creating a new mythology that takes readers into the world of snow and ice.

In Book Three: To Save the Life of Her Friend Kai, Gerda, an innocent young girl, embarks on a magical journey that will change her life forever. Along the way, she finds great power within herself and a gift she never imagined from her dead mother. As Gerda challenges one of the most powerful creatures in the world, the Snow Queen, she discovers that she is stronger than she ever imagined. The battlefield is set up for an all-out war of sorcery and magic.

“Rise Of The Snow Queen Book Three: The Story Of Gerda And Kai” is available in hardcover ISBN: 978-1-958221-02-0, paperback ISBN: 978-1-958221-03-7 and Kindle eBook: ASIN ‏: ‎ B0B4381FXZ. All sizes of printed books can be found at major book sellers such as Amazon, Walmart.com, Barnes and Noble, Nook, Books-A-Million, Powell’s City of Books and many other places around the world.

For more information, about his writing, visit the GW Mullins website at https://gwmullins.wixsite.com/books.

GW Mullins is a Native American/Cherokee author, photographer, and entrepreneur. He has been a published author for over 11 years. His writings have focused on paranormal and Native American studies.

Mullins has published several books on American Indian history/stories/fables. Among his books are the very successful “Star People, Sky Gods and Other Tales of the Native American Indians”, “Story Teller An Anthology Of Folklore From The Native American Indians”, “The Native American Story Book – Stories Of The American Indians For Children Volumes 1-5”, “The Native American Cookbook” and “Walking With Spirits Native American Myths, Legends, And Folklore Volumes 1 Thru 6”.

He has published the complete series of his ‘From The Dead Of Night’ science fiction books, including the best-selling titles – ‘Daniel Is Waiting’ and ‘Daniel Returns’.

His most recent work includes the “Rise Of The Snow Queen” series with the first book “The Polar Bear King” and the second “The War Of The Witches”. Mullins’ latest releases include two fantasy series for young adults, “Rise of the Dark-lighter Book One Dark Awakening” and the “Dream Walker” book series featuring “Enter the Sandman” and “Wide Awake In Dream Land.” Other releases include “Messages from The Other Side” (a non-fiction book about communicating with the dead) and the upcoming “Convergence” (a post-apocalyptic event of multiple book series coming Winter 2022 ).

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The novel that turns fatherhood into art https://harpmaker.net/the-novel-that-turns-fatherhood-into-art/ Fri, 17 Jun 2022 15:21:00 +0000 https://harpmaker.net/the-novel-that-turns-fatherhood-into-art/ Once, when my daughter was six months old, my mind started to wander while washing the dishes. The chore had become a soothing break from the baby’s incessant need. I was lost in thought as the hot water rushed over my hands, and this time I was trying to construct a theory from my dishes, […]]]>

Once, when my daughter was six months old, my mind started to wander while washing the dishes. The chore had become a soothing break from the baby’s incessant need. I was lost in thought as the hot water rushed over my hands, and this time I was trying to construct a theory from my dishes, how uplifting and rewarding the rote task could be. My working title for the exercise was The Dish of Sisyphus, which I was immensely proud of, before a scream came from the next room and dispelled my pot philosophy.

As with most things new parents don’t write down, I quickly forgot about this episode. A few months later, a friend – a childless writer friend – recommended Chris Bachelder’s 2011 novel, Abbott is waiting for youvolume. Best known for its National Book Award nominee The Return Special, which follows a group of friends who reunite each year to re-enact the football game that ended Joe Theismann’s career, Bachelder is acerbic and often painfully funny, employing humor to strike at the heart. My friend said I would like Abbott is waiting for you as much for its literary merits as for its view of fatherhood.

Getting recommended books is a typical postpartum rite of passage, and the market is full of parenting literature. Motherhood, as a topic, is covered from most angles imaginable: one can read Danzy Senna, Sheila Heti, Emily Oster and Dani McClain and gain an in-depth understanding of motherhood – across race, economics and gender. feminism. For fathers, the pool of options is a little shallower (Keith Gessen’s new memoir, Raising Raffiis a promising addition to Dad’s book canon).

Many dad books are presented as smart guides, memoirs, or manuals; and though most have helpful guidance, they seldom succeed in rising above their duty. Early authorship, when portrayed in literature, is often practical in the same way: it serves to color characters, plot, and themes, but rarely warrants sustained gaze. Take John Updike’s bunny running, which traces the struggle of a restless young father who abandons his family. By the time Rabbit returns home, later in the novel, his chances of proving he is a father are tragically lost. All this to say: fatherhood, as depicted in these books, is not usually shrewd, subtle, or consoling. Abbott is waiting for you is the antidote.

Bachelder’s short but indelible novel overflows with kitchen-sink wisdom; it was exactly what I lacked as a young father, struggling to make sense of my irrevocably changed existence. For all the depth one experiences in becoming a parent – the primordial love; humble wonder – there is also a lot of boredom and banality. Raising children is an immense task composed of many mind-numbing moments. Among the reasons Abbott is waiting for you is remarkable because it collects these moments and brings them to center stage. She makes everyday aspects of bourgeois parenthood objects of study, of tender observation.

Abbott is waiting for you takes place over the course of a summer and is divided into three sections: June, July and August. The titular Abbott is a teacher on break, his days spent caring for his 2-year-old daughter. He is filled with terror on many fronts – of his growing family (his wife is pregnant with their second child), of his job, and of the planet in peril – all exacerbated by the fact that he regularly searches for horrific information. online in his home office: a steamboat explosion, starving zoo animals, photographs of Chernobyl orphans.

The days are long, and sometimes the moments can seem to stretch on forever. Once, while taking his daughter for a walk, Abbott expends an inordinate amount of mental energy wanting time to pass so he can trade shifts with his wife, only to find himself home and realizing that almost no time has passed. Although the book is set around 15 years ago, it finds particular resonance with our current pandemic moment. Many of us have found ourselves parenting far more than we ever imagined, struggling to fill the hours with education and entertainment, while maintaining our sanity.

So what’s going on in this book? All and nothing; that is, there is virtually no plot to speak of. That is to say, it is very much like parenthood. The chapters are extremely brief (none exceeds four pages), written in the third person over Abbott’s shoulder. Most of the chapter titles, i.e. “In which Abbott sits in a parked car for quite a while”, are ironic. The tone is sometimes slightly academic and philosophical, sprinkled with Soare, in additionthe sand in additions; Abbott’s analytical attention to the bland moments of his life adds an irony to the non-action as it unfolds.

In late June, in a typically tedious scene, Abbott and his family are out shopping when his daughter vomits up raspberry compote in the car. As Abbott cleans up the mess, he summons three mythical heroes – Hercules, Sisyphus, and Prometheus – to help him deal with the mess. Ultimately, he is led to a paradox, which could serve as the central thesis of the novel. “The following statements are both true: (A) Abbott would not, given the opportunity, change an important part of his life, but (B) Abbott can not stand his life.”

Bachelder examines Abbott’s internal dilemma with a focus usually reserved for fictional men with greater ambition (Don DeLillo’s Jack Gladney or Colson Whitehead’s Ray Carney come to mind). Existential questions predominate for such characters, allowing only a fleeting look at parenthood. In a passage from his novel Information, Martin Amis describes the scene in a playground where the protagonist, Richard, is passing through a gray and monotonous morning with his child: their watch. They exchange slow nods of resignation and hear the wall of childish sounds from which no meaning stands out: his snaps, his snaps and his whippings. When I first read this passage, I was excited enough to read it out loud again, shouting “Shit! after I finished (it was also the first time I heard my daughter swear, as she was close enough to parrot). This penetrating look at the gloom of fatherhood resonated, but as soon as the paragraph ended, the novel and its protagonist quickly moved on to more pressing concerns.

But Abbott has nowhere to go. We are given a catalog of his troubles and struggles, learning how many times in a row he has read a book to his daughter; or how difficult it is to sprinkle leftover raisins from the folds of a high chair. We catch a glimpse of a dad sipping an evening cocktail amid the ruins of his toy-covered living room, in a brief moment of respite. Bachelder renders a scene that many beleaguered parents will recognize: how sometimes something as simple as a vacant seat on the sofa can feel like a throne.

Parenthood can be isolating and weird. If you find yourself first among equals with a child, you might mourn the loss of a lingua franca. As Bachelder writes: “Parenting is a distant and peculiar country with its own customs and its own language.”

For those parenting with a partner, navigating that country is also an integral part of the relationship. One of the great pleasures of this novel is the way Bachelder renders the fragility of Abbott’s marriage as he bears the weight of a new life. It is hard and often thankless work. There are fights, disagreements and a ton of psychological transfers. A chapter titled “Abbott Hogs the Mood” will ring emotionally for anyone in a relationship where parenthood is involved. Marriage is “a battle—clinically, a negotiation— on the possession of bad temper. Two parents can’t both be in a bad mood because the parents can’t stand it, and both parents are well aware of that. It’s a matter of give and take. And of love.

In the end, Abbott is preparing for the arrival of his second child. He paces the hospital room as nurses prepare his wife for a C-section. He reassures his wife that everything will be fine as their lives are about to change again.

Before you start Abbott is waiting for you, I was struck by its title, which reminded me of Samuel Beckett. A little like expect, pending suggests anticipation – perhaps the return of something. As parents, we all expect: the reconstitution of our independent selves; the former glory of our novels. But we have no choice but to stay here in this strange land, making sure its new inhabitants are safe and protected. Bachelder is a keen surveyor of this place, and he understands something more about Beckett’s infamous plea: I can not continue; I will continue. It is often the children who do this.

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Perfect Gold, coming-of-age visual novel, hits Switch tomorrow https://harpmaker.net/perfect-gold-coming-of-age-visual-novel-hits-switch-tomorrow/ Wed, 15 Jun 2022 22:06:54 +0000 https://harpmaker.net/perfect-gold-coming-of-age-visual-novel-hits-switch-tomorrow/ Yangyang Mobile has announced that Perfect Gold, its coming-of-age visual novel, is set to drop on To change. The title is scheduled for June 16, 2022. Perfect Gold stars Marion and Audrey, two female mages who escape from detention to attend a festival. You’ll accompany them on a journey to the magical town of Castlecoast […]]]>

Yangyang Mobile has announced that Perfect Gold, its coming-of-age visual novel, is set to drop on To change. The title is scheduled for June 16, 2022.

Perfect Gold stars Marion and Audrey, two female mages who escape from detention to attend a festival. You’ll accompany them on a journey to the magical town of Castlecoast and watch them get a second chance at love and friendship.

Learn more about the title in the preview below.

Perfect Gold: The Alchemy of Happiness is a short coming-of-age visual novel about two former friends who escape detention to celebrate the Sunflower Festival. In the magical town of Castlecoast, readers meet Audrey Clary, an alchemy student and heiress who secretly dreams of a different life, and Marion LaRue, a rebellious student of elemental magic looking for someone that she liked.

– A WLW (Women Who Love Women) Story for WLW: Follow a touching and touching story between two girls as they get a second chance at love and friendship.

– A short and sweet story: At around 30,000 words and with 2-4 hours of gameplay, Perfect Gold is just the game for those who like to relax with character-driven visual novels.

– 2 playable characters: see the story unfold through the eyes of Audrey and Marion.

– Fully Voiced: Features a cast of talented professional English voice actors who bring the characters to life.

– Vibrant and animated visuals: Immerse yourself in the magical town of Castlecoast, brought to life by animated characters, backgrounds and artwork.

– Interactive dialogue choices: Your choices influence the actions of the characters and will affect the ending of the story.

– Soundtrack: Listen to beautifully composed music tracks that accentuate the most moving beats in history.

And here is a trailer for Perfect Gold The Alchemy of Happiness:

Find the game digitally on the Switch eShop. Pricing is set at $7.99.

Source: Yangyang Mobile PR

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Author DL ​​Davies Publishes Breathtaking Dystopian Novel: A Delight for the Reader’s Soul https://harpmaker.net/author-dl-davies-publishes-breathtaking-dystopian-novel-a-delight-for-the-readers-soul/ Mon, 13 Jun 2022 21:27:00 +0000 https://harpmaker.net/author-dl-davies-publishes-breathtaking-dystopian-novel-a-delight-for-the-readers-soul/ Gee, book cover DL Davies SANTA MARIA, CALIFORNIA, USA, June 13, 2022 /EINPresswire.com/ — The world is becoming increasingly tense with all the major events happening day by day, from the terrifying effects of global plastic pollution to the threats of international war triggered by the bombing of Ukraine. An inevitable chaos is waiting to […]]]>

Gee, book cover

DL Davies

SANTA MARIA, CALIFORNIA, USA, June 13, 2022 /EINPresswire.com/ — The world is becoming increasingly tense with all the major events happening day by day, from the terrifying effects of global plastic pollution to the threats of international war triggered by the bombing of Ukraine. An inevitable chaos is waiting to be unleashed on this world. In the book “Gee” by DL Davies, a dystopian world unfolds within our grasp. On each page, Davies unveils a perfect ploy to draw emotional and mental tension to his readers through the story of a child named George Elandier Evansen or better known as “Gee”, living in a post-apocalyptic era.

DL Davies is a 79-year-old military veteran, welder, and auto mechanic who enjoys creating fictional realities of our world in both the past and the future. He is the profound author of the impressive Cuauhtémoc series with four standing books. Davies is proud of his works, with his book, Gee, at the forefront of its recent publication.

Besides the hectic plot and vividly exposed settings, Davies could easily instill fantasy into reality. An editorial review by Philip Zorarro of hollywood book review shared, “Underestimating Gee by his aw-shucks behavior is to your regret. Gee may be young but is scrappy. He will fight for what is right in every situation. A robbery from a bunch of bullies leads to the discovery of a large cache of goods. Gee possesses a magical ability to access these goods almost at will.”

There is greatness in every struggle one will encounter. Gee is the epitome of calm in the midst of chaos and justice in the midst of betrayal. The book takes readers to a place where survival is at its worst, a cannibal state. Despite his “gifts”, Gee still finds himself losing everyone he loves. However, this does not take away what remains of humanity in this young boy.

Zorarro then adds, “Gee is a positive story about the most negative scenario, living in a damaged world. Gee quickly proves a worthy protagonist who deserves support in his attempts to persevere in a decaying society. Abilities Gee’s supernatural powers are only surpassed by his depth of compassion. Author DL ​​Davies has created a character whose circumstances are tragic but who possesses an inner determination that speaks volumes. Gee has no respite within him, which makes it all the more interesting.

DL Davies is also a pretty enticing author. The Moving Words Review writes: “What I liked most was the style and language used by the author. The conversational style and well-thought-out humor serve up a seamless reading experience.” His readers have been constantly amazed since his Cuauhtémoc series, to discover this one-of-a-kind plot with Gee.

What could he post next? Hope to find out soon!

mike ramos
The moving words
write to us here

The Trailer – Gee

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Book fans flock to Burnham-On-Sea author Damien Boyd’s novel signing event https://harpmaker.net/book-fans-flock-to-burnham-on-sea-author-damien-boyds-novel-signing-event/ Sat, 11 Jun 2022 23:17:16 +0000 https://harpmaker.net/book-fans-flock-to-burnham-on-sea-author-damien-boyds-novel-signing-event/ Fans of Burnham-On-Sea author Damien Boyd’s novels gathered for a book signing in the town center on Saturday June 11 at the launch of his latest publication. A long line of customers waited outside the GW Hurley bookshop on Burnham’s high street to buy copies of the new novel. Damien then said: “A big thank […]]]>

Fans of Burnham-On-Sea author Damien Boyd’s novels gathered for a book signing in the town center on Saturday June 11 at the launch of his latest publication.

A long line of customers waited outside the GW Hurley bookshop on Burnham’s high street to buy copies of the new novel.

Damien then said: “A big thank you to Monika and the Hurleys team for organizing the event and to the people of Burnham for their continued support!”

In Carnival Blues, the new book in the hit DI Nick Dixon Crime series, the Somerset carnival season takes center stage.

Damien adds: “I hope I have managed to capture something of the unique atmosphere of carnival, both for those who are lucky enough to experience it and for those who have not yet had the pleasure.

The popular crime thriller series follows the exploits of Nick Dixon, now Chief Inspector of Police for Avon & Somerset, based at Express Park Police Centre, Bridgwater.

He says, “Crack aficionados will notice that I have taken several liberties with current practice and procedure. Needless to say, I did this in hopes of creating an entertaining mystery, but I’m reliably informed that squibbing is now so tightly regulated that the events depicted in Carnival Blues simply wouldn’t be possible these days. . Health and safety is paramount and rightly so. »

“In fact, I’m so confident that I’ve accepted the Bridgwater Guy Fawkes Carnival Squibbing Officer’s kind invitation to try it myself. I can’t wait!”

Damien adds: “Chief Inspector Nick Dixon arrives late for the Bridgwater Winter Carnival. He came to see the squibbing, the traditional fireworks display that dramatically closes the city’s November festivities. But when Avalon Carnival Club president Richard Webb’s firecracker is ignited, it explodes, engulfing him in flames.

“Dixon knows he just witnessed a killer make a very public statement. And he can’t help but think that’s just the beginning.

“With his suspicions confirmed at Burnham-on-Sea carnival forty-eight hours later, the race is on to find the killer before the next event in a nearby town.”

“Can Dixon stop the killings before more lives are lost?” And can he do it with the police professional standards investigators blowing down his neck? »

Carnival Blues will officially be released on Tuesday the 14the June and will be available in ebook, paperback and audio format.

Damien’s series starring DI Nick Dixon has sold over three million copies worldwide and has been translated into several different languages. Damien produces stories based on his own experience of twenty-five years in the legal profession, including a stint with the Crown Prosecution Service.

Her debut novel, As the Crow Flies, was published in April 2013 and became an international Kindle #1 bestseller. The sequels, Head in the Sand, followed by Kickback, Swansong, Dead Level and Death Sentence all received critical acclaim, with Head or Tails earning #1 Kindle bestseller status in the UK and Australia.

Click here to order a copy of the new book through Amazon

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